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The Elden Ring is a free-to-play fantasy action RPG where you create your own character with vast amounts of customization. Rise in the Land Between with grace, make a name for yourself, and become a protagonist in the epic new fantasy drama born from a myth.
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Mortality during critical care of adult patients with severe sepsis and septic shock continues to remain high. Septic shock is a common manifestation of sepsis. Sepsis is the nonspecific clinical manifestation of localized or systemic inflammation. Early recognition of septic shock and administration of appropriate interventions can result in better outcomes.
Objectives
==========
A better understanding of the pathophysiology of sepsis would allow for more focused therapies. Th~2~-like anti-inflammatory response is likely involved in the pathogenesis of sepsis. We sought to develop an assay that would be capable of measuring the Th1/Th2 cytokine shift and would be useful as an adjunctive diagnostic tool for sepsis.
Methods
=======
Female BALB/c mice (N=10) were used and randomized into three experimental groups: normal (N) received no treatment, sham (S) received 2 ml of NS i.p. and LPS (10 mg/kg i.v.), cecal-ligated (CL) received a partial ligation of the cecum. Animals were anaesthetized with ether. The surgery was performed using aseptic technique. Sham and CL group received 10 mg/kg i.v. of LPS while the other group received only NS (6 ml/kg i.p.). Blood samples were collected at 6 hours (N vs. S, LPS vs. NS), then, animals were killed with 120 mg/kg of ether at 12 hours. The samples were tested for TNF and IL-10 by ELISA.
Results
=======
In the cecal-ligated animals, both TNF and IL-10 increased (p=0.001) while in the NS group, only IL-10 increased (p
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Some 30 years after the fall of the One Kingdom, an ominous and destructive presence emerges. Detonation occurs in multiple parts of the world. Those who possess a certain spiritual power (Elden) know no bounds in fighting this monster….
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A Vast World Full of Excitement
A vast world where open fields with a variety of situations and huge dungeons with complex and three-dimensional designs are seamlessly connected. As you explore, the joy of discovering unknown and overwhelming threats await you, leading to a high sense of accomplishment.
Create Your Own Character
In addition to customizing the appearance of your character, you can freely combine the weapons, armor, and magic that you equip. You can develop your character according to your play style, such as increasing your muscle strength to become a strong warrior, or mastering magic.
An Epic Drama Born from a Myth
A multilayered story told in fragments. An epic drama in which the various thoughts of the characters intersect in the Lands Between.
Unique Online Play that Loosely Connects You to Others
In addition to multiplayer, where you can directly connect with other players and travel together, the game supports a unique asynchronous online element that allows you to feel the presence of others.
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The Elden Ring is a fantasy action RPG that combines the simplicity and intuitive controls of classic action RPGs, the vast world and engaging story of classic JRPGs, and the deep customization of character development in a grand and ever expanding fantasy saga.
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Developer: Art Grasso, Zack Beales, Jess Writzler, Ian Brereton, Devon DeRosier
Publisher: Art Grasso, Zack Beales, Jess Writzler, Ian Brereton, Devon DeRosier
What’s new:
>
05 Nov 2013 14:28:37 +0000 has released its list of games on their European Bonus Arcade of the Gencon.
Phobos (PC, PlayStation 3, PlayStation Vita, Wii U, Xbox 360, Android)
RPG-like 2-D turn-based battle system with splendid graphics and many over real fighters. The game allows players to play three different characters after morphing them into different allies. In order to enhance players’ tactical skills and fight choices, the battle system mixes players’ character settings with different game modes such as scrolling RPG and full of action.Raiders of Minas Tirith: The Secrets of Rapture now available on Xbox Live Arcade
The second week of Spring Fever is only one day away, and there are five games on XBLA this week to get you in the mood. Besides the new Tomb Raider, there is the August action game Urb Alien: Rampage, a unique twist on a music rhythm game, a city building simulator for the PS4, and another Racing game.
Raiders of Minas Tirith: Secrets of Rapture
This week on Xbox Live Arcade, Raider of Minas Tirith, Entertainment Earth’s exclusive release of Homefront: The Revolution. The game has a cliffhanger ending with a full story that goes from the “Raiders of the Southron Pass” through their escape from Minas Tirith and their efforts to steal the “Dragon Blade”, a weapon so powerful it can destroy Minas Tirith from the inside. This is told in the story of three players, an elf of the Southron Pass, a human solder in the Southron Pass, and a human mercenary in a remote outpost. In order to complete their destinies, they must unite against the Empire and the occupying force of the Southron Pass. It looks like Sony does like the idea of an 11 player game, because they also have this week’s release of the open world racing game Project Driven on the XBLA.
Ark Park
PlayStation 4 exclusive game Ark Park allows you to explore historic locations while competing in a drone dogfight
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