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World War Z Full Movie HD Download Torrent Full Movie Download HD Torrent.The role of tumor necrosis factor-alpha (TNF-alpha) in the pathogenesis of chronic liver disease and hepatic necroinflammatory disease.
Chronic hepatocyte injury of unknown etiology may progress to cirrhosis and may trigger or worsen hepatocellular carcinoma. Local production of factors including cytokines by hepatic cells or hematopoietic cells may play a role in the initiation or perpetuation of this process. To understand the role of such liver-derived cytokines in chronic hepatocellular damage, we review the role of TNF-alpha in the pathogenesis of chronic liver disease. The most abundant source of TNF-alpha is Kupffer cells, which may be activated by a variety of noxious stimuli including infection, alcohol or ischemia-reperfusion injury. Because TNF-alpha is a potent stimulator of hepatic synthesis and release of several cytokines, including IL-6 and nitric oxide, and because, the combined stimulation of such cytokines by TNF-alpha may amplify the liver injury, TNF-alpha, IL-6 and nitric oxide may mediate in the perpetuation of chronic hepatocellular injury. In order to prevent the progression of hepatic injury to cirrhosis and hepatocellular carcinoma, it may be useful to reduce the local production of TNF-alpha by inhibiting TNF-alpha synthesis or actions or to prevent the activation of Kupffer cells with IL-1 receptor or IL-1 blocking agents./*
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